With both Manchester City and Arsenal suffering from injuries to key team members, a draw looks the best bet for when the two sides meet at Eastlands on Saturday (November 22nd).
Joe Hart's ankle injury, which he sustained during last Sunday's away game against Hull, has left City boss Mark Hughes with just two fit goalkeepers to choose from - the relatively inexperienced pair of Kasper Schmeichel and Tobias Johansen.
As a result, the Premier League has agreed to allow Hughes to search for a temporary keeper until Hart recovers.
"We can bring a keeper in on loan so we will see what is out there as short-term cover," Hughes said.
"We will see who's available and see if it's worthwhile bringing anybody in."
Meanwhile, injury and suspension will rob Arsenal manager Arsene Wenger of a number of players including Bacary Sagna, Kolo Toure, Theo Walcott, Cesc Fabregas and Emmanuel Eboue.
A home win on Saturday is priced at 9/4 with William Hill and 5/2 with Betfair, while an away win is at 6/5 with both bookmakers.
A draw at 23/10 with William Hill and 13/5 with Betfair might therefore be the best option.